ESMO Publishes First-Ever Guidance on Validation Requirements for AI-Based Biomarkers in Oncology

 The European Society for Medical Oncology (ESMO) has released the Basic Requirements for AI-Based Biomarkers in Oncology (EBAI) framework, "the first comprehensive guidance for the safe, trustworthy and effective integration of AI-derived biomarkers in cancer care."  The framework provides guidance for developers, clinicians, regulators and healthcare institutions on means of integrating digital technologies in cancer care.  

To view the complete framework, click here. 

Source mentioned: 

ESMO Basic Requirements for AI-based Biomarkers In Oncology (EBAI)
DOI: 10.1016/j.annonc.2025.11.009

 

ESMO launches first congress on artificial intelligence and digital oncology: a milestone in shaping the future of cancer care

The European Society for Medical Oncology (ESMO) recently launched the inaugural Congress on Artificial Intelligence and Digital Oncology, taking place in Berlin this week, November 12-14, 2025.  With over 1100 participants scheduled to attend, the conference program will include discussions of: 

• Multimodal AI for clinical decision support, showcasing applications in molecular tumour boards and real-world data integration.
• AI-based biomarkers for precision oncology, featuring discussions on validation frameworks and predictive modelling, including the announcement of the imminent publication of the ESMO Basic Requirements for AI-based Biomarkers in Oncology (EBAI) framework
• Generative AI and large language models, with keynote lectures featuring speakers from Google DeepMind and Harvard Medical School.
• Digital health in practice, exploring wearable technologies, remote monitoring, decentralised trials.
• Ethics, regulation, and patient perspectives, addressing trust, explainability and the societal implications of AI in oncology.

To learn more about this conference, click here. 

Rucaparib monotherapy provides long-term benefit as first-line maintenance for patients with advanced ovarian cancer with and without HRD

 Results of ATHENA-MONO/GOG-3020/ENGOT-ov45, a phase III trial investigating rucaparib as a monotherapy in first-line maintenance treatment for advanced ovarian cancer patients, who presented in poster format at the recent ESMO (European Society of Medical Oncology) conference in Berlin, Germany. The study concluded that "sustained long-term improvement with rucaparib was observed in all subgroups examined regardless of HRD or risk status, with 29% of patients in the rucaparib group remaining progressing free at 5 years." 

To read more about this study, click here. 

Sources mentioned: 

• Kristeleit RS, Ghamande S, Lisyanskaya AS, et al. Rucaparib maintenance for newly diagnosed advanced ovarian cancer: interim overall survival, progression-free survival, and safety at 5 years of follow-up from the phase III ATHENA-MONO/GOG-3020/ENGOT-ov45 study . Annals of Oncology; Published online 18 October 2025. DOI: 10.1016/j.annonc.2025.10.007  
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• Abstract 1073P – Kristeleit RS, Ghamande S, Lisyanskaya AS, et al. 5-year progression-free survival (PFS) with rucaparib (RUCA) maintenance in patients with newly diagnosed advanced ovarian cancer in ATHENA-MONO (GOG-3020/ENGOT-ov45) . Annals of Oncology 2025;36(Suppl 2):S721-722.