Biomarker enrichment strategies

A recent article considers which clinical trial designs and analysis strategies are appropriate for use in phase III, biomarker-driven, randomised clinical trials, on the basis of pre-existing evidence that the biomarker can successfully identify patients who will respond to the treatment. In the article, authors describe enrichment strategies based on the use of prognostic biomarkers to separate a population into subgroups with better and worse outcomes, regardless of treatment. Read more here.