New model can predict therapy outcomes in prostate cancer with bone metastasis

To create the computational model, which they call “hybrid cellular automata,” researchers created simulations of different cell types involved in bone metastasis of prostate cancer, including two types of bone cells called osteoclasts and osteoblasts, and prostate cancer cells. They then created algorithms to simulate the interactions of these cells among themselves and with other bone metastasis-related factors in the microenvironment, including the proteins TGF-beta, RANKL, and other bone-derived factors. Read more here.