On March 25, 2016 new research shows that studying tumours early in development can reveal therapeutic targets that can boost the efficacy of treatments administered later in disease progression.
Patients with advanced Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant lung adenocarcinoma are currently treated with standard chemotherapy because of a lack of efficacious targeted therapies. In a translational research study, a group of Spanish investigators from the Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain reasoned that the identification of mediators of Kras signalling in early mouse lung hyperplasias might bypass the difficulties that are imposed by intratumour heterogeneity in advanced tumours, and that it might unveil relevant therapeutic targets. Read more here.
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