Monday, 19 December 2016

MEK inhibitor/Taxane combination active in triple-negative breast cancer

A small clinical trial demonstrated encouraging clinical activity in triple-negative breast cancer (TNBC) treated with a MEK inhibitor and a taxane. The combination of cobimetinib (Cotellic) and paclitaxel led to confirmed partial responses in 6 of 16 patients and 2 additional unconfirmed partial responses. Five of the 6 confirmed responses proved to be durable, persisting for about 20 weeks. “This is the first study to evaluate the combination of cobimetinib and paclitaxel in triple-negative breast cancer,” Adam M. Brufsky, MD, PhD, associate chief of hematology oncology, and co-director of the Comprehensive Breast Cancer Center at the University of Pittsburgh Medical Center, and colleagues concluded in a presentation at the 2016 San Antonio Breast Cancer Symposium. “The safety profile of combined cobimetinib and paclitaxel is manageable and consistent with the known safety profiles for each drug.

- See more here.

1 comment:

  1. MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but was completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023

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