Tamoxifen revolutionized personalized medicine as the first targeted therapy proven to save lives in cancer. The paradigm change proposed to block the breast tumor estrogen receptor (ER), apply long-term adjuvant therapy to block estrogen-stimulated recurrences, and apply the potential of tamoxifen to prevent breast cancer. These recommendations have been put into clinical practice for three decades. Please read the latest JAMA editorial on this therapy.
Study mentioned:
Abderrahman B, Jordan VC. Long-term Adjuvant Tamoxifen Therapy and Decreases in Contralateral Breast Cancer . JAMA Oncol. 2017;3(2):163-164. doi:10.1001/jamaoncol.2016.3324
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