Research conducted at the Francis Crick Institute has identified the means by which cancer cells are protected from oncolytic viruses, which trigger an immune response and thus have been used as a treatment mechanism to destroy cancer cells. Findings from the Crick Institute study determined that cancels cells exposed to cancer-associated fibroblasts (CAFs) "leads to inflammation that can alert the surrounding tissue, making it harder for viruses to invade and replicate within in the cancer cell."
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