Researchers at Baylor University and Phoenix Children's Hospital have discovered a method whereby DNA fragments in urine can differentiate between healthy individuals and those with cancer. According to study senior author Dr. Muhammed Murtaza, "certain regions of the genome are protected from fragmentation in urine from healthy individuals...but the same regions are more fragmented in patients with cancer."
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Study mentioned: Havell Markus, Jun Zhao, Tania Contente-Cuomo, Michelle D. Stephens, Elizabeth Raupach, Ahuva Odenheimer-Bergman, Sydney Connor, Bradon R. McDonald, Bethine Moore, Elizabeth Hutchins, Marissa McGilvrey, Michelina C. de la Maza, Kendall Van Keuren-Jensen, Patrick Pirrotte, Ajay Goel, Carlos Becerra, Daniel D. Von Hoff, Scott A. Celinski, Pooja Hingorani, Muhammed Murtaza. Analysis of recurrently protected genomic regions in cell-free DNA found in urine. Science Translational Medicine, 2021; 13 (581): eaaz3088 DOI: 10.1126/scitranslmed.aaz3088
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