A recently completed retrospective cohort study published by the Division of Cancer Care and Epidemiology at the Cancer Research Institute in Queen's University (Kingston, Ontario) indicated that nearly 50% of anticancer drug studies "demonstrated improved PFS [progression-free survival] (but) showed no improves in OS [overall survival] or QOL [quality of life]." Led by Dr. Bishal Gyawali, the study authors further mentioned that studies with negative QOL results are either published after considerable delay or not at all, however "focusing on non-curative settings only is a strength rather than a limitation of the analysis because the risk-benefit thresholds are different in curative settings."
To read more about this study, click here.
Source mentioned: Samuel JN, Booth CM, Eisenhauer E, et al. Association of Quality-of-Life Outcomes in Cancer Drug Trials With Survival Outcomes and Drug Class. JAMA Oncol 2022;8(6):879-886.
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