First-line serplulimab in combination with chemotherapy improves survival in patients with PD-L1-positive, locally advanced or metastatic oesophageal squamous cell carcinoma

 Findings from the ASTRUM-007 study, focusing on the the use of first-line Serplulimab and chemotherapy every 2 weeks for patients with locally advanced or metastatic PD-L1 positive oesophageal squamous cell carcinoma, were recently published in Nature Medicine. 

The respecified fine analysis of the study, assessed by a blinded Independent Radiological Review Committee (IRRC) determined that "Serplulimab plus chemotherapy significantly improved PFS compared with placebo plus chemotherapy with median PFS of 5.8 months and 5.3 months." 

To read more about this study, click here. 

Source mentioned: Song Y, Zhang B, Xin D, et al. First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial. Nature Medicine; Published online 2 February 2023. DOI: https://doi.org/10.1038/s41591-022-02179-2