NCI unveils comprehensive proteogenomic dataset to help cancer researchers unravel molecular mysteries

 The National Institutes of Health (NIH) is releasing data, via the National Cancer Institute (NCI) "that standardizes genomic, proteomic, imaging, and clinical data from individual studies of more than 1,000 tumors across 10 cancer types."  The purpose of this pan-cancer proteogenomic dataset is to speed up cancer research via sharing of data, namely cancer mutations and protein modifications.  Proteomics data can be accessed via the Proteomic Data Commons at https://pdc.cancer.gov/pdc/cptac-pancancer. Genomic and transcriptomic data can be accessed via the Genomic Data Commons at https://portal.gdc.cancer.gov and the Cancer Data Service at https://dataservice.datacommons.cancer.gov/.

Sources mentioned: 

1. Li Y, Dou Y, Leprevost FDV, et al. Proteogenomic data and resources for pan-cancer analysis. Cancer Cell. August 14, 2023. DOI: 10.1016/j.ccell.2023.06.009.

2. Geffen Y, Anand S, Akiyama Y, et al. Pan-Cancer analysis of post-translational modifications reveals shared patterns of protein regulation. Cell. August 14, 2023. DOI: 10.1016/j.cell.2023.07.013.

3. Li Y, Dou Y, Leprevost FDV, et al. Pan-Cancer proteogenomics connects oncogenic drivers to functional states. Cell. August 14, 2023. DOI: 10.1016/j.cell.2023.07.014.