Findings from the INCIPIENT study, an early phase I open-label study among participants with recurrent glioblastoma treated with intraventricularly delivered CARv3-TEAM-E T-cells, were recently published in the New England Journal of Medicine. The CARv3-TEAM-E T-cells "provides proof of principle that multiple surface antigens can be targeted simultaneously with the use of CAR T-cells and confirms that EGFR is a suitable immunotherapeutic target in glioblastoma."
To learn more about this study, click here.
Sources mentioned:
- Choi BD, Gerstner ER, Frigault MJ, et al. Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma. NEJM; Published online 13 March 2024. DOI: 10.1056/NEJMoa2314390
- Bagley SJ, Logun M, Fraietta JA, et al. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nature Medicine; Published online 13 March 2024. DOI: https://doi.org/10.1038/s41591-024-02893-z
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