Findings from the SU2C-SARC032 trial, conducted by the Sarcoma Alliance for Research through Collaboration (SARC) in 20 academic institutions across Australia, Canada, Italy, and the USA, was recently published in The Lancet. Led by Professor David G. Kirsch of the Princess Margaret Cancer entre in Toronto, results from the trial indicated "improvement in disease-free survival with addition of preoperative and postoperative pembrolizumab to preoperative radiation therapy and surgical resection for patients with stage III undifferentiated pleomorphic sarcoma or liposarcoma in the extremity or limb girdle."
To learn more about this trial, click here.
Source mentioned:
- Mowery YM, Ballman KV, Hong AM, et al. Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial. The Lancet; Published Online 12 November 2024: DOI: https://doi.org/10.1016/S0140-6736(24)01812-9
- Italiano A. Perioperative immunotherapy in soft tissue sarcomas. The Lancet; Published Online 12 November 2024. DOI: https://doi.org/10.1016/S0140-6736(24)02252-9
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