A recent study published in Science provides proof-of-concept that "generative artificial intelligence can offer a valid alternative approach to design precise, functional, and adaptable peptide binders capable of redirecting T cell responses against cancer antigens". While the authors are optimistic regarding AI-guided methods, they do caution that further investigation is required to determine long-term impact on immune cell function.
To learn more about this study, click here.
Source mentioned:
Johansen KH, Wolff DS, Scapolo B, Fernández-Quintero ML, Risager Christensen C, Loeffler JR, Rivera-de-Torre E, Overath MD, Kjærgaard Munk K, Morell O, Viuff MC, Lacunza I, Damm Englund AT, Due M, Gharpure A, Forli S, Rodriguez Pardo C, Tamhane T, Qingjie Andersen E, Haldrup Björnsson K, Fernandes JS, Voss LF, Thumtecho S, Ward AB, Ormhøj M, Reker Hadrup S, Jenkins TP. De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells. Science. 2025 Jul 24;389(6758):380-385. doi: 10.1126/science.adv0422. Epub 2025 Jul 24. PMID: 40705893.
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