The rationale for this adjuvant study was based on previous finding that adding cetuximab to FOLFOX was beneficial in patients with metastatic KRAS wt colon cancer. However, PETACC8 is the second trial to test cetuximab in the adjuvant setting, with findings from the US N0147 trial (cetuximab + mFOLFOX6) also failing to show any benefit. Read more
here.
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