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Wednesday, 28 May 2025

Supplemental breast cancer imaging techniques could lead to earlier detection of cancer in women with dense breasts

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 Results from the Breast Screening - Risk Adapted Imaging for Density (BRAID) study were recently published in The Lancet .  BRAID is "...
Wednesday, 21 May 2025

Patient and tumour characteristics may vary across treatment lines in a selected population of patients with mCRC included in randomised trials

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 Findings from a large-scale study conducted via the Aide et Recherche en Cancerologie Digestive (ARCAD) database of patients with metastati...
Thursday, 15 May 2025

Sun safety declining in Canada amid rise in skin cancer cases

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 A recently completed study from McGill University indicates a growing number of Canadians using less sun protection amidst increasing sun e...
Tuesday, 6 May 2025

InflaMix identifies CAR-T recipients with a preinfusion inflammatory profile indicative of high risk for CAR-T treatment failure

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 Findings from the use of InflaMix, a predictive, point-of-care-clinical tool, designed "to identify patients at high risk of treatment...
Wednesday, 23 April 2025

Potential for larger gene panels to increase the number of molecularly matched therapies in patients with advanced solid tumours

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 Results of ProfiLER-2, a multicentre, prospective study comparing a hospital homemade control gene panel (CTL) to "the commercially av...
Wednesday, 16 April 2025

Cancer mortality prediction for 2025 continues to show favourable trends in the European Union

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 A recently completed study of cancer mortality rates across the European Union (EU) over the past 5 years (2020-2025) indicate a lower mort...
Thursday, 10 April 2025

Adding chemotherapy to radiotherapy not associated with improved OS for patients with intermediate-risk cervical cancer

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 A population-based cohort study recently published in JAMA Oncology  found "no significant overall survival benefit from the addition ...
Wednesday, 2 April 2025

Suggesting a deadline in the invitation letter to FIT colorectal cancer screening results in more timely FIT return

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 Results from the timeframe and planning tool (TEMPO) study, part of the Scottish Bowel Screening Program, has determined that "includi...
Wednesday, 19 March 2025

Real-world patients with cancer show lower survival times and treatment-associated survival benefits compared to those included in RCTs

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 Findings from TrialTranslator, a machine-learning model involving randomized clinical trials (RCTs), indicates that "median overall su...
Wednesday, 12 March 2025

Distinct patient, tumour, treatment characteristics and a different pattern and risk of survival events over time between young BRCA1/2 carriers

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 Findings from a large-scale 20-year multicentre hospital=based retrospective cohort study were recently published in Journal of Clinical On...
Thursday, 6 March 2025

Clinical benefit of pembrolizumab in patients with previously treated advanced clear cell gynaecological cancers

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 Results from the United Kingdom-led PEACOCC phase II trial regarding the benefits of pembrolizumab on clear cell gynecological cancers was ...
Tuesday, 18 February 2025

Less frequent mammographic surveillance non-inferior compared with annual mammograms after diagnosis of breast cancer in women aged 50 years or older

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 Results of Mammo-50, a randomized phase III trial conducted across the United Kingdom on women aged 50 or older was recently published in T...
Wednesday, 5 February 2025

Cancer prevention and screening account for most cancer deaths averted among different interventions across the cancer control continuum

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 An extensive study of population-level mortality data, along with cancer prevention and screening interventions across common cancer in the...
Wednesday, 29 January 2025

Chemotherapy-free regimen of tucatinib and trastuzumab shows anti-tumour activity with durable responses in patients with HER2-mutated metastatic breast cancer

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 Results of the open-label phase II trial, SGNTUC-019, "evaluating tucatinib in combination with trastuzumab" in patients with HER...
Wednesday, 22 January 2025

Active monitoring promising for women with low-risk ductal carcinoma in situ

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Results of the intention-to-treat analysis from the COMET study, "a prospective randomized, pragmatic non-inferiority trial..." fo...
Monday, 16 December 2024

Blog postings will resume week of January 20, 2025

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  Dear Grey Horizon readers,  Thank you for your support of the blog over the past year.  Postings will resume the week of January 20, 2025....

Lung adenocarcinoma with mucinous histology

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 A recently completed study conducted amongst four academic institutions/cancer centres across the United States (Dana Farber/Brigham and Wo...
Tuesday, 10 December 2024

Prevention and screening have been major contributors to saving lives among five cancer types

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 A recent study published in JAMA Oncology  focusing on mortality from breast, cervical, colorectal, lung, and prostate cancer indicates tha...
Wednesday, 4 December 2024

Adding pembrolizumab to preoperative radiotherapy and surgery improves disease-free survival for patients with stage III soft tissue sarcomas of the extremity

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  Findings from the SU2C-SARC032 trial, conducted by the Sarcoma Alliance for Research through Collaboration (SARC) in 20 academic instituti...
Tuesday, 26 November 2024

Adding pembrolizumab to chemotherapy results in improved progression-free survival and overall survival in patients with advanced and recurrent cervical cancer regardless of bevacizumab use

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Final analysis of the Keynote-826 phase III trial, has shown that adding pembrolizumab to chemotherapy has increased progression-free surviv...
Wednesday, 13 November 2024

Webinar: Multi Cancer Early Detection Tools (MCED): Promises and Challenges

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The National Coalition for Cancer Survivorship (NCCS) recently hosted a webinar discussing Multi-Cancer Early Detection (MCED) tools.  The w...
Wednesday, 6 November 2024

National Coalition for Cancer Survivorship (NCCS) State of Cancer Survivorship: Survey Results

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 The National Coalition for Cancer Survivorship (NCCS) has released the results of a survey conducted on more than 2100 cancer patients, sur...
Friday, 1 November 2024

Short-course of induction chemotherapy followed by chemoradiotherapy significantly improves survival in patients with locally advanced cervical cancer

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 Results of INTERLACE, a phase III multicentre randomized study is the first to "show a significant survival advantage with the additio...
Monday, 21 October 2024

Social support linked with improved cancer screening in the U.S.; strongest for breast cancer screening

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 A new study conducted by the American Cancer Society has found a direct correlation between levels of social support and adherence to cance...
Wednesday, 16 October 2024

Biology of response and resistance to MAPK pathway targeted therapy in patients with BRAFV600E-mutated mCRC

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 Findings from the phase III BEACON metastatic colorectal cancer (mCRC) study were recently published in Nature Medicine. 10% of tumours in ...
Monday, 7 October 2024

Benefit in overall survival with neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab in patients with resectable, early-stage non-small cell lung cancer

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 Findings from the KEYNOTE-671 study, a randomized, placebo-controlled phase III trial, has shown that neoadjuvant prembrolizumab and cispla...
Wednesday, 25 September 2024

New cancer diagnoses did not rebound as expected following pandemic

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 A recent study appearing in the Journal of the National Cancer Institute  indicates "little evidence of a rebound in incidence" w...
Wednesday, 18 September 2024

Immunotherapy after surgery helps people with high-risk bladder cancer live cancer-free longer

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 A recently completed clinical trial, published in the New England Journal of Medicine  indicates that treatment with an immunotherapy drug ...
Wednesday, 11 September 2024

Breastfeeding after breast cancer is safe

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 Results from 2 studies presented at the recent ESMO Congress 2024 in Lugano, Switzerland, indicate that there is "no increase in recur...
Wednesday, 4 September 2024

Potential of molecular profiling to refine surgical and radiotherapy decision-making in patients with meningioma

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 Findings from the RTOG-0539 study, the largest meningioma cohort with multiplatform molecular ever conducted, was recently published in Nat...