Premenopausal high-risk breast cancer patients with luminal A tumours benefit from postmastectomy radiation

The PAM50 assay was used to identify a subgroup of patients with node positive breast cancer who derived increased long term benefit from chemotherapy plus radiation over chemotherapy alone following mastectomy; premenopausal women with luminal A tumours showed significantly decreased local disease recurrence from the addition of radiation to chemotherapy following surgery in an analysis of long term follow-up data from two small independent studies. Read more here.