A meta-analysis of first generation EGFR TKIs vs. chemotherapy in patients with wild type EGFR non-small cell lung cancer

A meta-analysis of 11 clinical trials with 1605 included patients with advanced non-small cell lung cancer (NSCLC), harbouring wild type (WT) epidermal growth factor receptor (EGFR), shows that previous treatment with chemotherapy compared with first generation EGFR tyrosine kinase inhibitors (TKIs) is associated with improvement in progression-free survival (PFS), but not with improvement in overall survival. Read more here.