UT Southwestern Medical Center neurology researchers have identified an important cell signaling mechanism that plays an important role in brain cancer and may provide a new therapeutic target. Researchers found that this mechanism -- a type of signaling termed constitutive or non-canonical epidermal growth factor receptor signaling -- is highly active in glioblastomas, the most common type of adult brain cancer and a devastating disease with a poor prognosis. When activated in cancer cells, it protects the tumor cells, making them more resistant to chemotherapy treatment. Read more
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