A new assay detects MET phosphorylation in tumor biopsies

March 31, 2016 - MET (hepatocyte growth factor receptor) is a trans-membrane, tyrosine kinase receptor whose aberrant signaling is implicated in cancer growth, progression, and metastasis. Currently, many drugs are in development that target MET kinase signaling; however, until now, no assay has been available to effectively measure MET pharmacodynamics directly in core biopsies of tumors, which is a critical capability for proof of mechanism studies to confirm intended drug action in patients. Read more here.