Results of the COMBI-AD study, compiled after almost 10 years of follow-up analysis, has concluded that "12 months of adjuvant treatment with dabrafenib plus trametinib was associated with better relapse-free survival and distant metastasis than placebo among patients with resected stage III melanoma." Further risk of death was 20% lower via the combined drug regimen compared to placebo. In addition, the COMBI-AD trial indicated overall survival after 3 years at 86% when patients were administered dabrafenib together with trametinib, compared to 77% when given a placebo.
To learn more about the COMBI-AD study, click here.
Source mentioned: Long GV, Hauschild A, Santinami M, et al. Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma. NEJM; Published online 19 June 2024. DOI: 10.1056/NEJMoa2404139
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