Blog postings will resume in early January 2025

 

Dear Grey Horizon readers, 

Thank you for your support of the blog over the past year.  Postings will resume in early January 2025. 

Lung adenocarcinoma with mucinous histology

 A recently completed study conducted amongst four academic institutions/cancer centres across the United States (Dana Farber/Brigham and Women's Cancer Center, MD Anderson Cancer Center, Memorial Sloan Kettering Cancer Center, and Massachusetts General Hospital), along with the University of Bologna in Italy have uncovered that "mucinous histology is seen in 10% of patients with lung carcinoma."  Further, the researchers determined that patients diagnosed with lung adenocarcinoma with mucinous histology, have never smoked.  These findings indicate the need to strongly consider mucinous histology in future lung cancer prognostications. 

To learn more about this study, click here. 

Source mentioned: 

Di Federico A, Hong L, Elkrief A, et al. Lung adenocarcinomas with mucinous histology: clinical, genomic, and immune microenvironment characterization and outcomes to immunotherapy-based treatments and KRASG12C inhibitors. Annals Of Oncology; Published online 2 December 2024. DOI: https://doi.org/10.1016/j.annonc.2024.11.014

Prevention and screening have been major contributors to saving lives among five cancer types

 A recent study published in JAMA Oncology focusing on mortality from breast, cervical, colorectal, lung, and prostate cancer indicates that cancer prevention and screening significantly contributes to reductions in death among these 5 cancer types.  According to Dr. Katrina Goddard, co-lead investigator for the study, "8 out of 10 deaths from these five cancers were averted over the past 45 years due to advances in prevention and screening."  Further, the study, looking at cancer mortality over 45 years (1975-2020) states that 5.94 million deaths were averted...[where] "prevention and screening interventions accounted for 4.75 million, or 80% of the averted deaths." 

To read more about this study, click here. 

Source mentioned: 

1. Goddard KAB, Feuer EJ, Mandelblatt JS, et al. Estimation of Cancer Deaths Averted From Prevention, Screening, and Treatment Efforts, 1975-2020. JAMA Oncol. Dec. 5, 2024. DOI:10.1001/jamaoncol.2024.538Exit Disclaimer
   

Adding pembrolizumab to preoperative radiotherapy and surgery improves disease-free survival for patients with stage III soft tissue sarcomas of the extremity

 

Findings from the SU2C-SARC032 trial, conducted by the Sarcoma Alliance for Research through Collaboration (SARC) in 20 academic institutions across Australia, Canada, Italy, and the USA, was recently published in The Lancet.  Led by Professor David G. Kirsch of the Princess Margaret Cancer entre in Toronto, results from the trial indicated "improvement in disease-free survival with addition of preoperative and postoperative pembrolizumab to preoperative radiation therapy and surgical resection for patients with stage III undifferentiated pleomorphic sarcoma or liposarcoma in the extremity or limb girdle." 

To learn more about this trial, click here. 

Source mentioned: 

• Mowery YM, Ballman KV, Hong AM, et al. Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial. The Lancet; Published Online 12 November 2024: DOI: https://doi.org/10.1016/S0140-6736(24)01812-9
• Italiano A. Perioperative immunotherapy in soft tissue sarcomas. The Lancet; Published Online 12 November 2024. DOI: https://doi.org/10.1016/S0140-6736(24)02252-9

Adding pembrolizumab to chemotherapy results in improved progression-free survival and overall survival in patients with advanced and recurrent cervical cancer regardless of bevacizumab use

Final analysis of the Keynote-826 phase III trial, has shown that adding pembrolizumab to chemotherapy has increased progression-free survival (PFS) and overall survival (OS) in patients with persistent, recurrent, or metastatic cervical cancer.   Following randomization of 617 patients, those who received bevacizumab indicated "grade >3 treatment-related adverse events occurred in 74% of patients in the pembrolizumab arm and 66.8% in the placebo arm." 

To learn more about the Keynote-826 trial, click here.  

Source mentioned: 

Lorusso D, Colombo N, Dubot C, et al. Pembrolizumab Plus Chemotherapy for Advanced and Recurrent Cervical Cancer: Final Analysis According to Bevacizumab Use in the Randomized KEYNOTE-826 Study. Annals of Oncology; Published online 9 October 2024. DOI: https://doi.org/10.1016/j.annonc.2024.10.002

Webinar: Multi Cancer Early Detection Tools (MCED): Promises and Challenges

The National Coalition for Cancer Survivorship (NCCS) recently hosted a webinar discussing Multi-Cancer Early Detection (MCED) tools.  The webinar, available at the following link, watch on YouTube, provides an overview of MCED tools cancer screening, from both a cancer survivor and patient advocate, as well as a renowned oncologist. 

To learn more about MCED tools, click here. 

National Coalition for Cancer Survivorship (NCCS) State of Cancer Survivorship: Survey Results

 The National Coalition for Cancer Survivorship (NCCS) has released the results of a survey conducted on more than 2100 cancer patients, survivors, and caregivers between August and September 2024. Findings from the survey, presented in report format, discuss treatment decision-making, post-treatment care, participation in clinical trials, side effects of treatment, and financial hardship.  

Click here to view the survey briefing video and download the survey results. 

Short-course of induction chemotherapy followed by chemoradiotherapy significantly improves survival in patients with locally advanced cervical cancer

 Results of INTERLACE, a phase III multicentre randomized study is the first to "show a significant survival advantage with the addition of induction chemotherapy before chemoradiotherapy in locally advanced cervical cancer."  5-year progression-free survival was significant: 72% in patients administered induction chemotherapy with chemoradiotherapy, compared to 64% receiving chemoradiotherapy alone. 

To learn more about this study, click here. 

Sources mentioned: 

• McCormack M, Eminowicz G, Gallardo D, et al. on behalf of the INTERLACE investigators. Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial. The Lancet 2024;404(10462):P1525-1525.
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• Duska LR, Randall LM. Progress in the treatment paradigms for locally advanced cervical cancer. The Lancet 2024;404(10462):p1494-1496.

Social support linked with improved cancer screening in the U.S.; strongest for breast cancer screening

 A new study conducted by the American Cancer Society has found a direct correlation between levels of social support and adherence to cancer screening.  According to principal scientist Dr. Jordan Baeker Bispo, "social relationships can influence cancer screening in a variety of ways, like shaping access to emotional support and material resources." 

To learn more about this study, click here. 

 

Biology of response and resistance to MAPK pathway targeted therapy in patients with BRAFV600E-mutated mCRC

 Findings from the phase III BEACON metastatic colorectal cancer (mCRC) study were recently published in Nature Medicine. 10% of tumours in patients with mCRC are comprised of BRAF mutations; the BEACON study "demonstrated that the BRAD inhibitor encorafenib plus the anti-EGFR monoclonal antibody cetuximab, with our without the MEK inhibitor binimetinib, improved overall survival (OS), objective response rate and progression-free survival (PFS) compared with cetuximab plus chemotherapy in patients with BRAF-mutated mCRC who has been previously treated."  

To learn more about the BEACON study, click here. 

Source mentioned: 

Kopetz S, Murphy DA, Pu J, et al. Molecular profiling of BRAF-V600E-mutant metastatic colorectal cancer in the phase 3 BEACON CRC trial. Nature Medicine; Published online 23 September 2024. DOI: https://doi.org/10.1038/s41591-024-03235-9

Benefit in overall survival with neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab in patients with resectable, early-stage non-small cell lung cancer

 Findings from the KEYNOTE-671 study, a randomized, placebo-controlled phase III trial, has shown that neoadjuvant prembrolizumab and cisplatin-based chemotherapy followed by adjuvant pembrolizumab "significantly improved overall survival compared with neoadjuvant chemotherapy along in patients with molecularly unselected, resectable stage II, IIIA or IIIB non-small cell lung cancer (NSCLC)."  Following a study of 797 NSCLC patients, 393 of whom received pembrolizumab while 400 received placebo, online survival estimates were "71% in the pembrolizumab group and 64% in the placebo group." 

To learn more about this study, click here. 

Sources mentioned: 

• Spicer JD, Garassino MC, Wakelee H, et al. on behalf of the KEYNOTE-671 investigators. Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone in patients with early-stage non-small-cell lung cancer (KEYNOTE-671): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet 2024;404(10459):P1240-1252.
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  Presley CJ, Owen DH. Improved survival for patients with lung cancer treated with perioperative immunotherapy. The Lancet 2024;404(10459):P1176-1178.
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  Garassino MC, Gao S, Liberman M, et al. Neoadjuvant pembrolizumab (pembro) or placebo (pbo) plus chemotherapy and adjuvant pembro or pbo for early-stage NSCLC: Subgroup analyses of the phase III KEYNOTE-671 study. Annals of Oncology 2024;35(Suppl 2):S778-S779.  

New cancer diagnoses did not rebound as expected following pandemic

 A recent study appearing in the Journal of the National Cancer Institute indicates "little evidence of a rebound in incidence" with regards to a decline in cancer diagnosis during 2020, the first year of the COVID-19 pandemic.  After scrutinizing 5 major cancer types (breast, prostate, lung, pancreatic, thyroid),  "cancer incidence rates overall [in 2021] for most specific cancers approached pre-pandemic levels", with the exception of breast cancer and pancreatic cancer, which showed an increase, while thyroid cancer diagnoses fell below pre-pandemic levels.  As such, 2021 has been considered "a transition year that was still affected by new variants and new waves of COVID-19 cases." 

Source mentioned: 

1. Howlader N, Chen H-S, Noone A-M, et al. Impact of COVID-19 on 2021 Cancer Incidence Rates and Potential Rebound from 2020 DeclineExit Disclaimer. JNCI. September 24, 2024. DOI: 10.1093/jnci/djae180.

Immunotherapy after surgery helps people with high-risk bladder cancer live cancer-free longer

 A recently completed clinical trial, published in the New England Journal of Medicine indicates that treatment with an immunotherapy drug "may nearly double the length of time people with high-risk muscle-invasive bladder cancer are cancer-free following surgical removal of the bladder."  According to Dr. Andrea Apolo from the National Cancer Institute, the drug in question, pembrolizumab, extension of the cancer-free period makes a considerable difference in the patient's quality of life.  

To read more about this trial, click here. 

Source mentioned: 

1. Apolo AB, Ballman KV, Sonpavde G, et al. Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma.Exit Disclaimer NEJM. September 15, 2024. DOI: 10.1056/NEJMoa2401726.

Breastfeeding after breast cancer is safe

 Results from 2 studies presented at the recent ESMO Congress 2024 in Lugano, Switzerland, indicate that there is "no increase in recurrence or new breast cancers in women who breastfeed after being treated for breast cancer." These findings provide the first evidence on breastfeeding in patients with a BRCA mutation.  Results from one of the studies dhows that of the 518 women who paused breast cancer treatment to have a baby, "317 had at least one live birth..and 62% breastfed."  The rate of breast cancer recurrence after 2 years was 3.6% in women who breastfed vs. 3.1% in those that did not.  

To learn more about these studies, click here. 

Sources mentioned: 

1. Lambertini M, Magaton IM, Hamy-Petit A-S et al. Safety of assisted reproductive techniques in young BRCA carriers with a pregnancy after breast cancer: results from an international cohort study. Abstract 266O presented at ESMO Breast Cancer 2024.
2. Partridge AH, Niman SM, Ruggeri M et al. Interrupting endocrine therapy to attempt pregnancy after breast cancer. NEJM 2023; 388: 1645-1656
3. 
   
4. Lambertini M, Blondeaux E, Agostinetto E et al. Pregnancy after breast cancer in young BRCA carriers. An international hospital-based cohort study. JAMA 2024; 331: 49-59

Potential of molecular profiling to refine surgical and radiotherapy decision-making in patients with meningioma

 Findings from the RTOG-0539 study, the largest meningioma cohort with multiplatform molecular ever conducted, was recently published in Nature Medicine.  Using retrospective data on 2,824 meningiomas, researchers found that "gross tumour resection was associated with longer progression-free survival across all molecular groups and longer overall survival in proliferative meningiomas." 

Click here to learn more about this study. 

Source mentioned: 

Wang JZ, Patil V, Landry AP, et al. Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. Nature Medicine; Published online 21 August 2024. DOI: https://doi.org/10.1038/s41591-024-03167-4

EMA recommends extension of therapeutic indications for encorafenib and binimetinib

 The European Medicine Agency (EMA) has recommended a change to marketing authorization for encorafenib and binimetinib for the treatment of adults with non-small cell lung cancer.  These drugs, when used in combination, as well as the drug cetuximab, may also be used to treat metastatic melanoma and metastatic colorectal cancer. 

To learn more about this recommendation, click here. 

Neoadjuvant chemotherapy with mFOLFIRINOX followed by chemoradiotherapy improves survival in patients with locally advanced rectal cancer

A recently unveiled long-term follow-up analysis of the UNICANCER-PRODIGE 23 study indicates that "neoadjuvant chemotherapy with mFOLFIRINOX followed by chemoradiotherapy improved overall survival and confirmed long-term disease-free survival and metastatic-free survival" in rectal adenocarcinoma patients. According to the UNICANCER-PRODIGE 23 study, patients receiving neoadjuvant mFOLFIRINOX had a 31% reduction in cancer recurrence. 

To learn more about the UNICANCER-PRODIGE 23 study, click here. 

Source mentioned:

Conroy T, Castan F, Etienne P-L, et al. Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial. Annals of Oncology; Published online 7 July 2024. DOI: https://doi.org/10.1016/j.annonc.2024.06.019

Generation X and millennials have higher risk of developing 17 cancers compared to older generations

A new study conducted by researchers at the American Cancer Society indicates a continuous rise in cancer diagnosis in post-Baby Boomer generations, particularly in breast, pancreatic, and gastric cancers.  According to Dr. Ahmedin Jemal, senior author of the study, "the increase in cancer rates among this younger group of people indicate generational shifts in cancer risk and often serve as an early indicator of future cancer burden.." 

To learn more about this study, click here. 

Study mentioned: 

Sung H, Jiang C, Bandi P, Minihan A, Fidler-Benaoudia M, Islami F, Siegel RL, Jemal A. Differences in cancer rates among adults born between 1920 and 1990 in the USA: an analysis of population-based cancer registry data. Lancet Public Health. 2024 Aug;9(8):e583-e593. doi: 10.1016/S2468-2667(24)00156-7. PMID: 39095135.

AI-based score as a selection tool for supplemental MRI after negative mammography detects many missed breast cancers

 The impact of AISmartDensity, a new artificial intelligence tool aimed to uncover undetected breast cancer after negative mammography screening was found to be "four times more efficient in terms of cancer detection" compared to traditional density and risk models, following MRI imaging.  Despite these encouraging findings, authors of this study di caution that certain cancers identified by BI-RADS D could well be missed by AISmartDensity, necessitating additional research on outcomes of effects and prognosis on cancer characteristics. 

To learn more about AISnartDensity, click here. 

Source mentioned: 

Salim M, Liu Y, Sorkhei M, et al. AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial. Nature Medicine; Published online 8 July 2024. DOI: https://doi.org/10.1038/s41591-024-03093-5

Adding olanzapine to standard triple antiemetic therapy for the prevention of carboplatin-induced nausea and vomiting

 A recently completed study from the Hamamatsu University School of Medicine in Japan has indicated that the addition of "olanzapine significantly improved nausea prevention in the overall and delayed phases in patients who received carboplatin."  Further, carboplatin, which has been classified as a moderate emetogenic chemotherapy agent, was not seen to cause serious adverse events in patients that were administered this drug. 

For further information, and to learn more about this study, click here. 

Source mentioned: 

Inui N, Suzuki T, Tanaka K, et al. Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial. JCO; Published online 4 June 2024. DOI: https://doi.org/10.1200/JCO.24.00278

40 % of cancer cases and almost half of all deaths in the U.S. linked to modifiable risk factors

 A new study conducted at the American Cancer Society attributes modifiable risk factors, namely smoking, obesity, alcohol consumption, physical inactivity, diet, and infections, as direct indictors of cancer death in nearly 50% of adult cancer deaths (30 years of age and older) in the United States. According to Dr. Farhad Islami, senior scientific director of cancer disparity research at the American Cancer Society, "despite considerable declines in smoking prevalence during the past few decades," 20% of cancer cases and 30% of all cancer deaths are a result of smoking.  Lisa Lacasse, president of the American Cancer Society Cancer Action Network, is adamant that "the cost to fully fund state tobacco control programs in tiny compared to the cost of tobacco-caused diseases and the potential tobacco-caused health care cost savings states stand to gain in the long term."  

To read more about this study, click here. 

Source mentioned: Islami F, Marlow EC, Thomson B, McCullough ML, Rumgay H, Gapstur SM, Patel AV, Soerjomataram I, Jemal A. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019. CA Cancer J Clin. 2024 Jul 11. doi: 10.3322/caac.21858. Epub ahead of print. PMID: 38990124.

Adjuvant dabrafenib plus trametinib associated with better RFS and DMFS than placebo among patients with resected stage III melanoma with BRAF V600 mutations

 Results of the COMBI-AD study, compiled after almost 10 years of follow-up analysis, has concluded that "12 months of adjuvant treatment with dabrafenib plus trametinib was associated with better relapse-free survival and distant metastasis than placebo among patients with resected stage III melanoma."  Further risk of death was 20% lower via the combined drug regimen compared to placebo. In addition, the COMBI-AD trial indicated overall survival after 3 years at 86% when patients were administered dabrafenib together with trametinib, compared to 77% when given a placebo. 

To learn more about the COMBI-AD study, click here. 

Source mentioned: Long GV, Hauschild A, Santinami M, et al. Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma. NEJM; Published online 19 June 2024. DOI: 10.1056/NEJMoa2404139

Belantamab mafodotin–containing triplets a PFS benefit among previously treated patients with relapsed or refractory multiple myeloma

 Results of DREAMM-7, a randomized phase III study, were recently published in the New England Journal of Medicine.  According to DREAMM-7, "treatment with belantamab mafodotin, bortezomib and dexamethasone (BVd regimen) conferred a significant benefit...with respect to progression-free survival (PFS).." among melanoma patients. After a period of 18 months, overall survival for patients treated with the BVd regimen was 84% compared 73% in patients treated with daratumumab, bortezomib and dexamethasone (DVd). These findings indicate strong support for BVd as a preferred treatment option for patients with multiple myeloma. 

To read more about this study, click here. 

Sources mentioned: 

• Hungria V, Robak P, Hus M, et al. for the DREAMM-7 Investigators. Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma. NEJM; Published online 1 June 2024. DOI: 10.1056/NEJMoa2405090
• Dimopoulos MA, Beksac M, Pour L, et al. for the DREAMM-8 Investigators. Belantamab Mafodotin, Pomalidomide, and Dexamethasone in Multiple Myeloma. NEJM; Published 2 June 2024. DOI: 10.1056/NEJMoa240340

Grey Horizon postings will resume week of July 2, 2024

 To all Grey Horizon readers, 

Thank you for your continued support of this blog.  Postings will resume the week of week of July 2, 2024.  

Cost of care discussions rarely documented for patients with advanced cancer

 A recently completed population study by researchers at the American Cancer Society and the National Cancer Institute shows "cost discussions were infrequently documented in medical records" of patients with advanced non-small cell lung cancer and melanoma.  According to lead study author Dr. Robin Yabroff, scientific vice president of health services research at the American Cancer Society, cost discussions were noted in only 20.3% of non-small cell lung cancer and 24% of melanoma patients.  

To read more about this study, click here. 

Study mentioned: Yabroff KR, Mittu K, Halpern MT. Cost-of-care discussions for individuals with advanced non-small cell lung cancer and melanoma: Findings from a large, population-based pilot study. Cancer. 2024 Jun 13. doi: 10.1002/cncr.35380. Epub ahead of print. PMID: 38869706.

Neoadjuvant nivolumab and ipilimumab leads to a pathological response in a high proportion of patients with locally advanced dMMR colon cancer

 Results of NICHE-2, "a large phase II study involving patients with locally advanced mismatch repair-deficient (dMMR) colon cancers..." was recently published in the New England Journal of Medicine. As mentioned by the study authors, staging of dMMR colon cancer presents a number of challenges, due to microsatellite instability associated with "false positive enlarged lymph nodes owing to immune infiltration."  

To read more about the NICHE-2 study, click here. 

Source mentioned: 

• Chalabi M, Verschoor YL, Batista Tan P, et al. Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair–Deficient Colon Cancer. N Engl J Med 2024;390:1949-1958.
• Cercek A. Neoadjuvant Treatment of Mismatch Repair–Deficient Colon Cancer — Clinically Meaningful? N Engl J Med 2024;390:2024-2025.

NIH scientists develop AI tool to predict how cancer patients will respond to immunotherapy

 A proof-of-concept study developed by researchers at the National Cancer Institute utilizes artificial intelligence from a blood test "to predict whether someone's cancer will respond to immune checkpoint inhibitors." The study, conducted on 2881 patients treated with immune checkpoint inhibitors across 18 solid cancer types, provided accurate predictions on likely response to immune checkpoint inhibitor, as well as lifespan, overall survival, and cancer reoccurrence. 

To read more about the study, click here. 

Study mentioned: 

1. Chang T, Cao Y, Sfreddo HJ, et al. LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic featuresExit Disclaimer. Nature Cancer. June 3, 2024. DOI: 10.1038/s43018-024-00772-7.

    

    

Adding 24 Months of ADT improves metastasis-free survival in patients with prostate cancer treated with postoperative radiotherapy

 A new study recently completed at the Institute of Clinical Trials and Methodology at University College London has unveiled that adding 24 months of ADT [androgen deprivation therapy] improved metastasis-free survival in prostate cancer patients undergoing postoperative radiotherapy.  

The study authors further explain that survival benefit "should be weighed against the extended duration of the well-known adverse events associated with ADT, such as sexual dysfunction, metabolic syndrome, and osteoporosis."   

To learn more about this study, click here. 

Sources mentioned: 

• Parker CC, Kynaston H, Cook AD, et al. on behalf of the RADICALS investigators. Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial. The Lancet; Published online 16 May 2024. DOI: https://doi.org/10.1016/S0140-6736(24)00549-X 
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• Parker CC, Clarke NW, Cook AD, et al. on behalf of the RADICALS investigators. Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial. The Lancet; Published online 16 May 2024. DOI: https://doi.org/10.1016/S0140-6736(24)00548-8 
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• Pollack A, Dal Pra A. Androgen deprivation therapy combined with postoperative radiotherapy for prostate cancer management. The Lancet; Published online 16 May 2024. DOI: https://doi.org/10.1016/S0140-6736(24)00802-X

Biomarker analyses in patients with HER2-positive or HER2-low gastric and gastro-oesophageal junction cancer treated with trastuzumab deruxtecan

 Findings of the DESTINY-Gastric01 randomized study, comparing trastuzumab deruxtecan vs. third line or later chemotherapy in HER2-positive gastric or gastro-esophageal cancer patients, was recently published in Nature Medicine. While the authors acknowledge that further investigations in larger studies is needed, "the biomarkers identified in this analysis are being investigated and validated in additional studies." 

To learn more about DESTINY-Gastric01, click here. 

Source mentioned: Shitara K, Bang Y-J, Iwasa S, et al. Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial. Nature Medicine; Published online 14 May 2024. DOI: https://doi.org/10.1038/s41591-024-02992-x

Projected estimates of cancer in Canada 2024

 New research published in the Canadian Medical Association Journal summarizes the expected impact of cancer in Canada in 2024, including projections of new cancer cases and mortality, arranged according to gender and province/territory for 23 different types of cancer.  

Projected numbers for 2024 include 247,100 cancer diagnoses and 88,100 cancer deaths in Canada.  While rates of lung, colorectal, and prostate cancer are expected to decrease, other cancers, including liver, bile duct, kidney, melanoma, and non-Hodgkin lymphoma are expected to rise. 

To learn more about this research, click here. 

Source mentioned: 

Darren R. Brenner, Jennifer Gillis, Alain A. Demers, Larry F. Ellison, Jean-Michel Billette, Shary Xinyu Zhang, JiaQi Leon Liu, Ryan R. Woods, Christian Finley, Natalie Fitzgerald, Nathalie Saint-Jacques, Lorraine Shack, Donna Turner

CMAJ May 2024, 196 (18) E615-E623; DOI: 10.1503/cmaj.240095