Results from APOLLO, a randomized phase III study, indicated that a "near-chemotherapy free treatment of arsenic trioxide in combination with all-trans retinoic acid plus low-dose idarubicin significantly improved outcomes of patients with newly diagnosed, high-risk acute promyelocytic leukaemia." A median follow-up of 37 months indicated that 2-year event free survival was 88% in patients receiving all-trans retinoic acid and arsenic trioxide vs. 71% in patients receiving all-trans retinoic acid plus anthracycline-based chemotherapy.
To read more about the APOLLO study, click here.
Sources mentioned:
- Platzbecker U, Adès L, Montesinos P, et al. on behalf of the SAL, AMCL-CG, AML-SG, OSHO, PETHEMA, HOVON and GIMEMA study groups. Arsenic Trioxide and All-Trans Retinoic Acid Combination Therapy for the Treatment of High-Risk Acute Promyelocytic Leukemia: Results From the APOLLO Trial . JCO; Published online 18 August. DOI: https://doi.org/10.1200/JCO-25-00535
- Iland HJ. APOLLO: Optimizing the Treatment of High-Risk Acute Promyelocytic Leukemia With All-Trans Retinoic Acid and Arsenic Trioxide While Minimizing the Role of Chemotherapy . JCO; Published online 18 August 2025. DOI: https://doi.org/10.1200/JCO-25-01496
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