A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. This finding may help researchers decipher how to inhibit the growth of tumors that have become resistant to other treatments. Read more here.
Study mentioned: Burikhanov R, et al. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4. Cell Rep. 2014 Jan 7. pii: S2211-1247(13)00765-1. [Epub ahead of print] PMID: 24412360
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