Genomic analysis reveals targetable kinase-activating alterations in Ph-like acute lymphoblastic leukaemia

More than one-quarter of young adults with the most common form of acute lymphoblastic leukaemia (ALL) have a high-risk subtype with a poor prognosis. Philadelphia chromosome-like ALL (Ph-like ALL) was found to be characterised by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors, according to multi-institutional research led by St. Jude Children's Research Hospital investigators. The study appears in the 11th September 2014 issue of The New England Journal of Medicine. Read more here.