Validation of genome-driven integrated classification of breast cancer

IntClust is a classification of breast cancer comprising ten subtypes based on molecular drivers identified through the integration of genomic and transcriptomic data from around 1,000 breast tumours and validated in a further 1,000.  The new research findings, published in the journal Genome Biology, indicate that IntClust subtypes are reproducible, show clinical validity and best capture variation in genomic drivers. IntClust is likely to become increasingly relevant as more targeted biological therapies become available. Read more here.