A comprehensive analysis of the genomes of nearly 500 papillary thyroid carcinomas (PTC) – the most common form of thyroid cancer – has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive disease development.
Investigators with The Cancer Genome Atlas (TCGA) Research Network identified new molecular subtypes that will help clinicians determine which tumors are more aggressive and which are more likely to respond to certain treatments.
The researchers, led by Thomas Giordano, M.D., Ph.D., University of Michigan, Ann Arbor, and Gad Getz, Ph.D., Broad Institute of MIT and Harvard, Cambridge, Massachusetts, reported their results online October 23, 2014, in Cell.
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