Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer

A new study shows SIRT6—a protein known to inhibit the growth of liver and colon cancers—can promote the development of skin cancers by turning on an enzyme that increases inflammation, proliferation and survival of sun-damaged skin cells. Previously considered protective, SIRT6 is part of a family of seven proteins called sirtuins that help regulate genomic stability and prevent some of the genetic flaws associated with aging. SIRT6 helps repair DNA damage, which can lead to cancer. This study reveals its activity can vary from one tissue type to another. Read more here.