Signaling mechanism could be target for survival, growth of tumor cells in brain cancer

UT Southwestern Medical Center neurology researchers have identified an important cell signaling mechanism that plays an important role in brain cancer and may provide a new therapeutic target. Researchers found that this mechanism -- a type of signaling termed constitutive or non-canonical epidermal growth factor receptor signaling -- is highly active in glioblastomas, the most common type of adult brain cancer and a devastating disease with a poor prognosis. When activated in cancer cells, it protects the tumor cells, making them more resistant to chemotherapy treatment. Read more here.