Datopotamab deruxtecan shows promising activity in heavily pretreated advanced HR-positive/HER2-negative and triple-negative breast cancers

 TROPION-PanTumor01, a phase I study on the effects of datopotamab deruxtecan on heavily pretreated advanced HR-positive/HER2-negative breast cancer and triple-negative breast cancer (TNBC) indicated a "confirmed objective response rate of 26.8% in patients with HR-positive/HER2-negative breast cancer and 31.8% in patients with TNBC." While the study authors acknowledge that the number of patients in each cohort (41 HR-positive/HER2-negative and 44 in TNBC) use of datopotamab deruxtecan is being compared with single-agent chemotherapy as a possible second or third line treatment option.  

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Source mentioned: Bardia A, Krop IE, Kogawa T, et al. Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2– and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study. JCO; Published online 23 April 2024: DOI: https://doi.org/10.1200/JCO.23.01909