Blog postings will resume in July 2025

 

Dear Grey Horizon readers, 

Thank you for your continued support of this blog.  Postings will resume in July 2025.  

Vepdegestrant results in longer PFS than fulvestrant in previously treated patients with ESR1-mutated, ER-positive, HER2-negative ABC

 Results from VERITAC-2, an open-label randomized phase III study conducted on "ER-positive HER2- negative advanced breast cancer patients...receiving endocrine therapy plus a CDK4/6 inhibitor" to measure progression-free survival, was reported at the 2025 ASCO Annual Meeting.  Based on findings from VERITAC-2, "vepdegestrant monotherapy showed encouraging clinical activity in patients who had received multiple previous lines of treatment for ER-positive, HER-2 negative ABC." 

To read more about VERITAC-2, click here. 

Sources mentioned: 

• Campone M, De Laurentiis M, Jhaveri K, et al. for the VERITAC-2 Study Group. Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer . NEJM; Published online 31 May 2025. DOI: 10.1056/NEJMoa2505725
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• Hamilton EP, De Laurentiis M, Jhaveri K, et al. Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, randomized, phase 3 VERITAC-2 study . J Clin Oncol 2025;43(suppl 17):abstr LBA1000. DOI: 10.1200/JCO.2025.43.17_suppl.LBA1000