Genetic variations that are linked with the onset of Barrett's esophagus, a pre-cancerous condition of the lower end of the esophagus, have been identified for the first time. The discovery of variations in regions on two chromosomes makes it possible to develop screening tests for people at high risk of developing the disease. A multi-national team of researchers led by Prof. Janusz Jankowski of the Blizard Institute of Cell and Molecular Science at Queen Mary, University of London, UK, has identified genetic variations on chromosome 6p21 and on chromosome 16q24. Read more here.
Study mentioned: The Esophageal Adenocarcinoma Genetics Consortium. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet. 2012 Sep 9. doi: 10.1038/ng.2408. [Epub ahead of print] PMID: 22961001
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