Regulating glucose metabolism in immune cells may extend and enhance their ability to fight cancer and infection, according to a new mouse model study by NCI investigators. Investigating the mechanism of glucose metabolism in CD8+ T cells, whose role is to destroy virally infected cells or tumor cells, the scientists found that varying levels of glucose acted as a metabolic regulator in whether or not the cells became more specialized. Read more here.
Study mentioned: Sukumar M, et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest. Published online September 16, 2013.
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