A phase III study of tivantinib plus erlotinib did not meet a primary endpoint in patients with locally-advanced or metastatic, non-squamous NSCLC

Although a large, phase III trial of tivantinib plus erlotinib for the treatment of patients with locally-advanced or metastatic, non-squamous, non-small cell lung cancer (NSCLC) did not meet its primary endpoint of prolonging overall survival, promising progression-free survival and overall response rate results were seen in these patients. Following trial cessation by an independent review board, an analysis of data by molecular subgroup is underway. From the molecular analysis, it is expected to answer whether clinical benefit in patients with tumours that overexpress MET is observed. Read more here.