Research led by St. Jude Children’s Research Hospital scientists has linked an inherited gene variation to a nearly four-fold increased risk of developing a pediatric acute lymphoblastic leukemia subtype that is associated with a poor outcome. The high-risk variant was found in the GATA3 gene. Researchers reported the high-risk version of the gene was more common among Hispanic Americans and other individuals with at least 10 percent Native American ancestry than those of other ethnic backgrounds. Read more here.
Study mentioned: Perez-Andreu V, et al. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet. 2013 Oct 20. [Epub ahead of print] PMID: 24141364
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