A new report by investigators from the International Agency for Research on Cancer (IARC) describes how key aspects of cancer development can be modelled in cultured cells treated with carcinogenic chemicals. This study uses innovative genomics and bioinformatics approaches to establish specific mutation fingerprints left in the cellular DNA by carcinogens during cellular immortalization and clonal expansion, two characteristics of cancer development.
Olivier M, et al. Modelling mutational landscapes of human cancers in vitro. Scientific Reports (NPG). 4:4482; published on 27 March 2014.
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