Wednesday, 26 March 2014

Study reveals a major mechanism driving kidney cancer progression

In a recent issue of Cancer Cell, researchers from Chicago and Beijing describe the mechanisms that enable hypoxia to cause the overexpression of SPOP. They show that hypoxia also stimulates the shuttling of SPOP out of the nucleus, where it normally prevents tumor growth, to the cytoplasm, where it shuts down protective pathways that should restrict tumor growth. Read more here.

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