Patients with NSCLC treated with chemo before surgery live longer

POEMs Research Summaries - Your daily update for the Latest Patient Oriented Evidence that Matters

Clinical question
Do patients with non-small-cell lung cancer have better outcomes when receiving chemotherapy before surgery?

Bottom line
In this meta-analysis, patients with non-small-cell lung cancer (NSCLC) treated with chemotherapy before surgery had better overall survival and fewer recurrences than patients treated with surgery alone. (LOE = 1a)

Reference
NSCLC Meta-analysis Collaborative Group. Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data. Lancet 2014;383(9928):1561-1571.

Study design
Meta-analysis (randomized controlled trials)

Funding
Government

Allocation
N/A

Setting
Various (meta-analysis)