Researchers at the University of California, San Diego School of Medicine and San Diego Moores Cancer Center have uncovered new evidence in the clonal evolution of chronic lymphocytic leukemia (CLL). Since the degree of CLL progression varies greatly, some patients may be symptom-free for several years, while others are affected quite rapidly. Dr. Thomas Kipps, lead author of the study, states that, prior to therapy, "the patterns of genes expressed by CLL cells appear to converge, regardless of whether or not the patient had aggressive versus indolent disease at diagnosis." Findings from this study will thus enable researchers to understand how other cancers evolve over time.
To read more about this study, click here.
Study mentioned: Chuang HY et al. Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression. Blood 2012 Jul 26 [Epub ahead of print]. PMID 22837534
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