Scientists at the National Cancer Institute have found that a protein, FBXW7, which acts as a tumor suppressor, is also important for the reduction in strength of inflammatory pathways. This study is the first to describe how FBXW7 acts in cancer cells as well as in cells of the immune system to attenuate inflammatory signaling, which is accomplished by reducing the levels of C/EBPdelta, a protein that regulates the expression of many genes. Read more here.
Study mentioned: Balamurugan K, et al. FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4. Nature Communications. 4: 1662. Published online 09 April 2013 .
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