Novel AKT pathway inhibitor, ARQ 092, demonstrates safety, effective target inhibition

The researchers have confirmed that the novel oral agent ARQ 092 inhibits the AKT pathway and has a manageable safety profile in patients with a variety of advanced solid tumours. Hyperglycemia indicated effective AKT pathway inhibition, it occurred prior to dose-limiting skin toxicity and could be treated according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. Read more here.