A noncoding RNA promotes pediatric bone cancer

A new study in the Journal of Clinical Investigation indicates that a long noncoding RNA named Ewing sarcoma-associated transcript 1 (EWSAT1) is a critical target of the fusion protein and contributes to the complex network of changes that occur in Ewing Sarcoma. A team led by Alejandro Sweet-Cordero at Stanford University identified increased expression of EWSAT1 in cancer cells from children with Ewing sarcoma. Further they showed that this noncoding RNA is important for cancer cell growth and associated with the repression of several genes downstream of EWS-FLI1. Read more here.