Rewiring metabolism slows cancer growth

A University of Utah-led study reports that cancers select against a protein complex called the mitochondrial pyruvate carrier (MPC), and re-introduction of MPC in colon cancer cells impairs several properties of cancer, including growth. The research, which appears online in Molecular Cell, implicates changes in a key step in metabolism – the way cellular fuel is utilized – as an important driver of colon cancer that is also likely to be important in many other cancer settings. Read more here.