TopBP1 a sweet spot for treatment in multiple cancers

A compound called calcein may act to inhibit topoisomerase IIβ-binding protein 1 (TopBP1), which enhances the growth of tumors, said researchers from Baylor College of Medicine in a report that appears online in the journal Nature Communications. "The progression of many solid tumors is driven by de-regulation of multiple common pathways," said Dr. Weei-Chin Lin, associate professor of medicine- hematology & oncology, and a member of the NCI-designated Dan L. Duncan Cancer Center at Baylor. Among those are the retinoblastoma (Rb), PI(3)K/Akt and p53 pathways, which, when de-regulated, lead to accumulation and structural alteration of TopBP1. Read more here.