Scientists have tracked down and quantified the diverse origins of cells that drive fibrosis, the incurable, runaway wound-healing that scars and ultimately destroys organs such as the lungs, liver and kidneys. “Answering a fundamental question about the origin of these cells by identifying four separate pathways involved in their formation allows us to look at ways to block those pathways to treat fibrosis,” said senior author Raghu Kalluri, Ph.D., M.D., MD Anderson chair and professor. Read more here.
Study mentioned: Lebleu VS, et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013 Jun 30. [Epub ahead of print] PMID: 23817022
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