May 12, 2016 - In this study, the investigators from the Institut Gustave Roussy, Villejuif, France aimed to identify if short-term preoperative palbociclib is associated with decreased proliferation and early biomarker changes in patients with early breast cancer. Untreated patients were randomised 3:1 to oral palbociclib 125 mg daily for 2 weeks until the day before the surgery vs no treatment.
Short-term preoperative palbociclib treatment in patients with early breast cancer significantly decreased Ki67; this effect depended on molecular subtypes and correlated with changes in pRB, suggesting that activity of palbociclib could be the main determinant of its short-term effect on proliferation. Read more here.
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