Metastasis-directed therapy for oligometastatic solid tumours in histology-specific context

 Findings from EXTEND, "a multicentre, open-label, parallel group, superiority-design phase II randomized study conducted among patients with oligometastatic solid tumours" was recently presented at the European Society of Radiotherapy and Oncology (ESTRO) Congress in Stockholm.  EXTEND is the first randomized study for oligometastatic kidney cancer, a phase II ASTROS trial "comparing metastasis-directed therapy followed by pembrolizumab or surveillance." The EXTEND trial thus emphasizes consideration of control arm with potential adaption to novel systemic therapies. 

Click here to learn more about the EXTEND trial. 

Source mentioned: 

Sherry AD, Haymaker C, Wang S, et al. Addition of Metastasis-Directed Therapy to Standard of Care for Oligometastatic Solid Tumors: Primary Analysis of All Tumor-Histology Baskets of the Phase II Randomized EXTEND Trial . JCO; Published online 16 May 2026. DOI: 10.1200/JCO-25-02856