Little is known about the biology of BRAF mutant (BRAFm) colorectal cancer captured by gene expression and the manuscript proposed by Popovici V et al. describes a BRAF gene signature that allows an accurate identification of BRAF mutant samples, and which, when applied to BRAF wild-type tumors, identified additional colon cancer samples that manifests a similar gene expression pattern. Read the European Society for Medical Oncology summary here.
Study mentioned: Popovici V, et al. Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer. J Clin Oncol. 2012 Apr 20;30(12):1288-95. PMID 22393095
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