ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives a substantial reduction in lung metastases, according to a study published June 8 in the Journal of The National Cancer Institute. Read the news story here.
Study mentioned: Mochizuki S, et al. Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand Factor. J Natl Cancer Inst. 2012 Jun 1 [Epub ahead of print] PMID 22636800
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