Notch—the protein that can help determine cell fate—maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell. Read more here.
Study mentioned: Valdez JM, et al. Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity. Cell Stem Cell. 2012 Nov 2;11(5):676-88. PMID: 23122291
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